Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning
نویسندگان
چکیده
منابع مشابه
Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents
Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). OP poisoning causes major cholinergic syndrome. Current medical counter-measures mitigate the acute effects but have limited action against OP-induced brain damage. Bioscavengers are appealing alternative therapeutic approach because they neutralize OPs in bloodstream before they reach physiological target...
متن کاملexploring motivation and english test preparation strategies of iranian pre-university candidates during and at the end of test preparation period for konkur examination
the current study aimed at investigating the relationship between motivation and test preparation strategies (tpss) used by iranian pre-university students in their preparation period for the university entrance exam (uee). due to the importance of uee in iran, this study also attempted to show its impact on these two important variables. to this end, 100 pre-university students in an iranian p...
The mode of recovery of cholinesterase activity in vivo after organophosphorus poisoning. 1. Erythrocyte cholinesterase.
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متن کاملThe mode of recovery of cholinesterase activity in vivo after organophosphorus poisoning. 2. Brain cholinesterase.
Previous investigators (Frawley, Hagan & Fitzhugh, 1952; Davison, 1955; Kewitz & Nachmansohn, 1957) have observed that the rate of recovery in vivo of inhibited brain true cholinesterase depended on which inhibitor was used. With diiwopropyl phosphorofluoridate (Frawley et al. 1952; Davison, 1955; Kewitz & Nachmansobn, 1957) recovery was slow, whereas with tetraethyl pyrophosphate (Davison, 195...
متن کاملFrom the Research of Cholinesterase Reactivators to the Effective Therapy of Organophosphate/nerve Agent Poisoning
Nerve agents belong to the most toxic organophosphates (OP) in the group of cholinesterase inhibitors. They can be used as chemical warfare agents and, they can be (and were) misused by terrorists, as happened in Matsumoto city (1994) and Tokyo subway (1995). Sarin was used in these cases. Medical protection against their effect (i.e. antidotal treatment) is of prime importance (Bajgar 2004, 20...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2017
ISSN: 0022-3042
DOI: 10.1111/jnc.14026